Nandrolone decanoate, commonly known by the brand name Deca-Durabolin®, is an anabolic steroid used primarily to treat certain medical conditions. Here’s a detailed description:

Description

Nandrolone decanoate 100 mg is a synthetic anabolic steroid that mimics the effects of the male hormone testosterone. It is administered via intramuscular injection.

Uses

• Anemia: It is used to manage anemia associated with chronic kidney failure by increasing hemoglobin and red blood cell mass.
• Osteoporosis: In some countries, it is also prescribed as an adjunct therapy for senile and postmenopausal osteoporosis.
• Other Conditions: It may be used to treat AIDS-associated wasting syndrome, chronic kidney disease, and certain types of breast cancer

Nandrolone decanoate works through several mechanisms to exert its effects:

1. Conversion to Nandrolone: Once administered, nandrolone decanoate is hydrolyzed to nandrolone in the body.
2. Androgen Receptor Interaction: Nandrolone enters cells via receptor-mediated endocytosis and binds to the androgen receptor. This binding causes a conformational change in the receptor, allowing it to enter the nucleus.
3. Gene Transcription Regulation: Inside the nucleus, the androgen receptor-nandrolone complex dimerizes and binds to specific DNA segments, regulating the transcription of various genes involved in muscle growth and erythropoiesis (red blood cell production)¹.
4. Protein Synthesis and Nitrogen Retention: Nandrolone enhances protein synthesis and nitrogen retention in muscles, promoting muscle growth and repair.
5. Erythropoietin Production: It stimulates the production of erythropoietin, which increases red blood cell production.
6. Suppression of Luteinizing Hormone (LH): By mimicking the negative feedback mechanism of testosterone, nandrolone decanoate suppresses the secretion of LH

Nandrolone Decanoate 100 mg, an anabolic steroid, has several contraindications and precautions to be aware of:

Contraindications

1. Carcinoma of the breast or prostate: It should not be used in male patients with known or suspected carcinoma of the breast or prostate.
2. Hypercalcemia in breast cancer: In females with breast cancer and hypercalcemia, nandrolone can stimulate osteolytic resorption of bones..
3. Pregnancy: It is contraindicated during pregnancy due to the risk of masculinization of the fetus.
4. Nephrosis or nephrotic phase of nephritis: It should not be used in patients with these conditions.

Precautions

1. Diabetes: Monitor diabetic patients carefully as nandrolone can affect blood sugar levels.
2. Conditions influenced by edema: Use with caution in patients with cardiovascular disease, migraine, seizure disorders, or renal impairment.
3. Hepatic impairment: Patients with liver issues should use nandrolone cautiously.
4. Elderly: Older adults may be more sensitive to the effects of nandrolone.
5. Virilization in women: Discontinue use if signs of virilization (development of male characteristics) occur in women.

It’s important to use nandrolone only under the supervision of a healthcare provider to manage these risks effectively.

Nandrolone decanoate, commonly known as Deca-Durabolin, can interact with several other medications. Here are some key interactions to be aware of:

1. Antidiabetic Drugs: Nandrolone decanoate may interfere with the concentration of antidiabetic medications, potentially affecting blood sugar control.
2. Anticoagulants: It can enhance the anticoagulant activity of coumarin-type agents, increasing the risk of bleeding.
3. Corticosteroids: Concomitant use with corticosteroids may increase the risk of edema.
4. Thyroid Hormones: Anabolic steroid therapy may decrease thyroxine-binding globulin, resulting in altered thyroid hormone levels.

It’s important to consult with a healthcare provider before starting nandrolone decanoate, especially if you are taking other medications. They can help manage potential interactions and adjust dosages as necessary.

Nandrolone decanoate 100 mg can cause a range of adverse reactions and side effects. Here are some of the most common and serious ones:

Common Side Effects

• Headaches
• Acne
• Diarrhea
• Nausea and vomiting
• Swelling (especially in feet, ankles, and legs)
• Trouble sleeping (insomnia)
• Mood changes (including depression, irritability, and aggression)

Serious Side Effects

• Allergic reactions: Rash, hives, itching, swelling of the mouth, face, lips, tongue, or throat, and difficulty breathing.
• High calcium levels: Weakness, confusion, fatigue, headache, upset stomach, constipation, or bone pain.
• Liver problems: Dark urine, fatigue, loss of appetite, stomach pain, light-colored stools, vomiting, or yellowing of the skin or eyes.
• Virilization in women: Deepening of the voice, facial hair growth, acne, and menstrual irregularities.
• Cardiovascular issues: Edema, with or without congestive heart failure.
• Genitourinary effects: Oligospermia, decreased ejaculatory volume, prostatic enlargement, priapism, and excessive sexual stimulation.

Rare but Severe Side Effects

• Peliosis hepatis: Blood-filled cysts in the liver.
• Hepatic neoplasms: Liver tumors.
• Hepatocellular carcinomas: Liver cancer.

It’s crucial to consult with a healthcare provider if you experience any of these side effects or have concerns about using nandrolone decanoate. They can provide guidance and adjust your treatment as necessary.

Nandrolone decanoate is contraindicated during pregnancy and breastfeeding due to potential risks to the fetus and infant.

Pregnancy

• FDA Pregnancy Category X: Nandrolone decanoate should not be used during pregnancy as it can cause virilization of the external genitalia of a female fetus.
• Potential Risks: There are no controlled data in human pregnancy, but anabolic steroid use, particularly during the first trimester, may lead to significant adverse effects¹.

Breastfeeding

• Excretion in Milk: There is no data on the excretion of nandrolone into human milk.
• Recommendation: Due to the potential for adverse effects on the nursing infant, it is recommended to either discontinue the drug or stop breastfeeding

To ensure the effectiveness and safety of nandrolone decanoate 100 mg, follow these storage guidelines:

• Temperature: Store below 30°C (86°F).
• Light: Keep the medication away from direct light.
• Moisture: Store in a dry place, away from moisture.
• Freezing: Do not freeze the medication.
• Children: Keep out of reach of children.
• Expiry: Do not use the medication past its expiry date