Methenolone Enanthate 100 is a dihydrotestosterone derived anabolic steroid. Methenolone Enanthate 100 contains methenolone enanthate, a long- acting methenolone ester producing a rapid onset of serum methenolone with a continued duration of action of 5 to 7 days after IM injection. Methenolone Enanthate 100 is moderately anabolic with limited androgenic properties. Methenolone cannot aromatize to estrogen, reducing estrogenic side effects, and has a favorable safety profile among anabolic agents.
CLINICAL PHARMACOLOGY
Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects and adverse reactions demonstrate the androgenic properties of these drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are thus similar to those of male sex hormones. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testes. During exogenous administration of anabolic androgens, endogenous testosterone release is inhibited through inhibition of pituitary luteinizing hormone (LH). At large doses, spermatogenesis may be suppressed through feedback inhibition of pituitary folliclestimulating hormone (FSH).
Methenolone is a dihydrotestosterone derivative which cannot be aromatized to estrogen and which acts upon the androgen receptor stimulating anabolism through increased nitrogen retention and protein synthesis in muscle tissue. Methenolone enanthate in a single dose pharmacokinetic study has demonstrated a mean elimination half-life of 6 days.
As an alternate or adjunctive therapy in patients for the promotion of weight gain following
weight loss and/or muscular atrophy associated with extensive surgery, chronic infections,
long term hospitalization, or severe trauma. To compensate for protein catabolism
consequent to corticosteroid therapy.
Because androgens may alter serum cholesterol concentration, caution should be used
when administering these drugs to patients with a history of myocardial infarction or coronary
artery disease. Patients on oral anticoagulant therapy require close monitoring especially
when androgens are started or stopped.
Diabetics: androgens may alter the metabolism of oral hypoglycemic agents or may change
insulin sensitivity in patients with diabetes mellitus which may require adjustment of dosage
of insulin and other hypoglycemic drugs.
Oral hypoglycemic agents: may inhibit the metabolism of oral hypoglycemic agents which
may require adjustment of dosage.
Anticoagulants: Patients on anticoagulants should be carefully monitored during anabolic
steroid therapy as anabolic steroids may increase sensitivity to oral anticoagulants. Patients
should be monitored regularly during anabolic steroid therapy, particularly during initiation
and termination of therapy.
Side effects of metenolone enanthate include:
Masculinization symptoms (acne, increased hair growth, voice changes, increased sexual desire)
Androgenic effects (virilization in women, acne)
Cardiovascular effects (adverse impacts on cholesterol levels)
Liver toxicity
Hormonal imbalance
Psychological effects
Fluid and electrolyte retention
Increased bone growth and skeletal weight
Pregnancy
Metenolone enanthate is not recommended during pregnancy. It can cause harm to the fetus due to its androgenic properties, which can interfere with normal fetal development1.
Breastfeeding
Breastfeeding while using metenolone enanthate is also not advised. Most medications can pass into breast milk to some extent, and androgens like metenolone enanthate can potentially affect a nursing infant2. If you need to take this medication, it’s crucial to discuss alternatives or the possibility of stopping breastfeeding with your healthcare provider
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain. NOTE: Warming and shaking the vial should redissolve any crystals that may have formed during storage temperatures lower than recommended.
