Testosterone cypionate injection is use to treat males whose bodies do not make enough natural testosterone, a condition called hypogonadism. Testosterone is a male hormone responsible for the growth and development of the male sex organs and maintenance of secondary sex characteristics. This medicine is not for use in female patients.

Testosterone cypionate is a slow-acting testosterone ester that we compound in a medium chain triglyceride oil-base to create an injectable hormone replacement medication.  The cypionate ester absorbs more slowly than other forms of testosterone, giving each injection a longer therapeutic action.  In addition, the oil-based excipient is a compatible solubilizing base that helps make the compound uniform and ideal for depot injection.  Because of the longer acting nature of cypionate and the oil excipient helping to slow the release of the active ingredient, patients are expected to require less frequent administration of our testosterone cypionate compound.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms: Oil

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-alpha-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine should not be used by female patients, especially if pregnant or breastfeeding. Testosterone may cause birth defects if a pregnant person comes in contact with the medicine. Make sure your doctor knows if your sexual partner is pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.

This medicine may increase your risk of having heart or blood vessel problems, including a heart attack or stroke. Tell your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, faintness, headache, nausea, vomiting, trouble breathing, trouble seeing or speaking, or unusual sweating.

This medicine may increase the risk of prostate cancer, especially in older males. Make sure your doctor knows if you have prostate cancer, or if anyone in your family has prostate cancer.

This medicine may cause blood clotting problems (eg, deep vein thrombosis, pulmonary embolism). Tell your doctor right away if you have anxiety, chest pain, coughing, dizziness or lightheadedness, fainting, fast heartbeat, pain, redness, or swelling in the arm or leg, or trouble breathing.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

In some cases, this medicine may decrease the amount of sperm males make and affect the ability to have children. Talk with your doctor before you use this medicine if you plan to have children.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause edema (fluid and sodium retention). Check with your doctor right away if you have a decrease in amount of urine, swelling of the fingers, hands, feet, or lower legs, trouble breathing, or weight gain.

This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor.

This medicine may cause changes in the level of cholesterol and fats in your blood. If this condition occurs, your doctor may give you a medicine to adjust the cholesterol and fats. Talk to your doctor if you have concerns.

Hypercalcemia (high calcium in the blood) may occur in patients taking this medicine. Check with your doctor right away if you have stomach pain, confusion, constipation, depression, dry mouth, increased urination, loss of appetite, metallic taste, or muscle weakness.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

This medicine may increased risk of bone growth problems in children. Your doctor will check your child's bone growth every 6 months.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

INCIDENCE NOT KNOWN
Acne
anxiety
bleeding gums or nose
bluish lips or skin
chest pain, discomfort, or tightness
chills
clay-colored stools
confusion
constipation
cough
dark urine
decrease in amount of urine
diarrhea
difficulty in speaking
difficulty swallowing
discouragement
dizziness or lightheadedness
double vision
dry mouth
enlargement of penis or testes
eye pain
fast heartbeat
feeling sad or empty
fever
growth of pubic hair
headache
hives, itching, skin rash
inability to move the arms, legs, or facial muscles
inability to speak
increased urination
irritability
lack or slowing of normal growth in children
loss of appetite
loss of interest or pleasure
metallic taste
muscle weakness
nausea
pain, redness, or swelling in the arm or leg
pain or discomfort in the arms, jaw, back or neck
painful or prolonged erection of the penis
penile pain during erection
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
rapid increase in height
ringing in the ears
slow speech
stomach pain
sweating
swelling
swelling of the breasts or breast soreness
swelling of the fingers, hands, feet, or lower legs
thirst
tiredness
trouble breathing
trouble concentrating
trouble sleeping
unpleasant breath odor
unusual tiredness or weakness
vomiting
vomiting of blood
weight gain or loss
yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

SYMPTOMS OF OVERDOSE
Blurred vision
inability to speak
seizures
severe or sudden headache
slurred speech
temporary blindness
weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

INCIDENCE NOT KNOWN
Decreased or increased interest in sexual intercourse
inability to have or keep an erection
increased or loss in sexual ability, desire, drive, or performance
pain and swelling at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects.

Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].
Protect from light.